Adolescent exposure to the psychedelic 25C-NBOMe in rats induces lasting competitive avoidance through disrupted hippocampal–prefrontal synchrony
Nature Neuroscience July 20, 2026 Zhi-Peng Yu, Zhong-Yu Zhang, Qiong Li et al.
Psychedelics, known for prosocial effects and therapeutic potential in psychiatry, are often first used during adolescence, yet their enduring impact on social behavior and its underlying circuits remain unclear. Here we show that repeated exposure to the serotonergic psychedelic drug 25C-NBOMe during adolescence, but not exposure in adulthood, induced lasting competitive avoidance in male...