Mark H Pollack

2 papers in the library · 2 citations · publishing 2013-2025

Papers

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneous RE104: A Double-Blind, Randomized, Single Ascending Dose Placebo-Controlled Study.

Journal of Clinical Psychopharmacology July 21, 2025 Guy Ludbrook, Nathan Bryson, Beatrix Taylor et al. 2 citations

A single subcutaneous dose of RE104, a prodrug of the synthetic psychedelic 4-OH-DiPT, was generally safe and well-tolerated in 48 healthy adults with prior psychedelic experience. Doses from 5 to 40 mg produced no serious adverse events or deaths; most side effects were mild to moderate and occurred under supervision. The drug appeared rapidly in the blood, with peak levels reached in 1.0 to 1.25 hours and a half-life of 2.72 to 4.12 hours. Exposure increased proportionally with dose. Plasma levels correlated with drug effects and mystical experiences, and higher doses produced more complete mystical experiences. The psychoactive experience lasted 3 to 4 hours, shorter than psilocybin, suggesting a favorable therapeutic profile.

DOI: 10.1097/jcp.0000000000002047 Full text Psilocybin 4‑substituted tryptamines Re104 Hallucinogens +14

Loving-Kindness Meditation practice associated with longer telomeres in women.

Brain, behavior, and immunity August 1, 2013 Elizabeth A Hoge, Maxine M Chen, Esther Orr et al.

People who practice Loving-Kindness Meditation (LKM), a Buddhist-derived technique focusing on unselfish kindness toward all, tended to have longer telomeres—a cellular marker linked to slower aging—than non-meditators. In women, the difference was statistically significant even after accounting for body mass index and past depression. The study compared 15 LKM practitioners with 22 controls and found no significant differences in age, gender, race, education, or trauma exposure, though controls had higher BMI and lower rates of past depression. The results suggest LKM practice might influence telomere length, particularly in women, though the small sample size limits certainty.

DOI: 10.1016/j.bbi.2013.04.005 Full text