Assessment of complement cascade components in patients with major depressive disorder.
Brain, Behavior, and Immunity July 1, 2025 Brandi Quintanilla, Dede Greenstein, Ashutosh Tripathi et al. 7 citations
Recent evidence suggests that the rapid-acting antidepressant ketamine has immune regulatory functions. The complement system is an important component of the innate immune response and plays a key role in synaptic plasticity. An increase in complement component 3 (C3) expression was previously found in the prefrontal cortex of individuals with depression. Given the complement system's role in...
DOI: 10.1016/j.bbi.2025.03.009 (opens in new tab)
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Depressive disorder
Immune function
Antidepressant
Depression major depression
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