Cost-utility and biological underpinnings of Mindfulness-Based Stress Reduction (MBSR) versus a psychoeducational programme (FibroQoL) for fibromyalgia: a 12-month randomised controlled trial (EUDAIMON study)
BMC Complementary and Alternative Medicine February 27, 2016 A. Feliu‐Soler, Xavier Borràs, M. Peñarrubia-María et al.
This 12-month randomized controlled trial will test whether adding Mindfulness-Based Stress Reduction (MBSR) to usual care for fibromyalgia syndrome (FMS) is more effective and cost-effective than usual care plus a psychoeducational program (FibroQoL) or usual care alone. The study will enroll 180 adult FMS patients and measure functional, quality of life, distress, and cost outcomes, along with brain structure and function (via MRI) and inflammatory markers (IL-6, IL-8, IL-10, and high-sensitivity CRP) in half the participants. The results are expected to clarify whether MBSR produces brain and inflammatory changes and whether it is a cost-effective add-on therapy for FMS.