Design and rationale of a comparative effectiveness trial evaluating transcendental meditation against established therapies for PTSD.
Contemporary Clinical Trials September 1, 2014 Thomas Rutledge, Sanford Nidich, Robert H Schneider et al.
A randomized controlled trial is underway comparing Transcendental Meditation (TM) to Prolonged Exposure (PE) therapy and a health education control for posttraumatic stress disorder in 210 Veterans meeting DSM-IV criteria. The study will measure PTSD symptoms, depression, mood, quality of life, behavioral factors, and physiological/biochemical and gene expression mechanisms at 0 and 3 months. The hypothesis is that TM will be noninferior to PE and superior to the control on changes in PTSD symptoms as assessed by the Clinician Administered PTSD Scale. This protocol aims to establish TM's efficacy for PTSD in Veterans and identify underlying mechanisms.