Chiral analysis of ketamine enantiomers in human urine and hair: Application to authentic cases of ketamine use.
Journal of Pharmaceutical and Biomedical Analysis August 15, 2025 Zhen Zhang, Yan Shi, Meiting Lin et al.
Ketamine, which possesses important anesthesia and antidepressant properties, has been used clinically in its racemate form. In the 1990s, the single enantiomer S-ketamine began to be used for clinical use. In 2019, an antidepressant S-ketamine hydrochloride nasal spray hit the market. Therefore, a method for chiral analysis of ketamine is particularly important, as this could reveal the types...