Role of Supramammillary Nucleus Glutamatergic Neurons in Modulating Consciousness Transitions during Propofol Anesthesia in Mice.
Anesthesiology October 1, 2025 Jia-Yan Li, Ye-Hui Wu, Yi-Han Wang et al.
Glutamatergic neurons in the supramammillary nucleus (SuM) have previously been shown to be pivotal parts of the wakefulness-sleep regulation system. However, whether they play a role in propofol-mediated modulation of consciousness remains unclear. This study hypothesized that glutamatergic neurons in the SuM contribute to the regulation of altered states of consciousness under propofol...