Effect of cannabinol, tetrahydrocannabivarin and cannabidiol on voluntary alcohol consumption.
Alcohol and alcoholism (Oxford, Oxfordshire) March 17, 2026 Ieva Poceviciute, Martynas Arbaciauskas, Rokas Buisas et al.
Previous studies have demonstrated that the endocannabinoid system plays a significant role in the development of alcohol use disorder (AUD), and CB1 receptor antagonists/inverse agonists show promise as a novel AUD pharmacotherapy. However, these compounds failed in clinical trials due to the severe psychiatric side effects. Non-psychoactive phytocannabinoids may have a better safety profile...