Performance of male C57BL/6J mice and Wistar rats in the water maze following various schedules of phencyclidine treatment.
Behavioural Pharmacology February 1, 2005 J Podhorna, M Didriksen
In order to establish an animal model of cognitive impairments relevant to schizophrenia, we set out to obtain an optimal treatment protocol with phencyclidine (PCP) that would lead to robust cognitive impairment with minimal PCP-related adverse effects. Effects of various doses (0.63-5 mg/kg), pre-treatment period (0, 3, 7 and 10 days before the beginning of acquisition) and treatment...