Differential role of dose and environment in initiating and intensifying neurotoxicity caused by MDMA in rats
BMC Pharmacology and Toxicology August 5, 2019 Ibrahim M. Shokry, Connor J. Shields, John J. Callanan et al.
Background MDMA causes serotonin (5-HT) syndrome immediately after administration and serotonergic injury in a few days or weeks. However, a serotonin syndrome is not always followed by serotonergic injury, indicating different mechanisms responsible for two adverse effects. The goal of present study was to determine causes for two adverse events and further test that dose and environment have...