Immediate and Persistent Effects of Salvinorin A on the Kappa Opioid Receptor in Rodents, Monitored In Vivo with PET.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology December 1, 2015 Michael S. Placzek, Genevieve C Van de Bittner, Hsiao‐ying Wey et al.
Monitoring changes in opioid receptor binding with positron emission tomography (PET) could lead to a better understanding of tolerance and addiction because altered opioid receptor dynamics following agonist exposure has been linked to tolerance mechanisms. We have studied changes in kappa opioid receptor (KOR) binding availability in vivo with PET following kappa opioid agonist...