Kappa Opioids, Salvinorin A and Major Depressive Disorder.
Current Neuropharmacology 2016 George T Taylor, Francesca Manzella
Opioids are traditionally associated with pain, analgesia and drug abuse. It is now clear, however, that the opioids are central players in mood. The implications for mood disorders, particularly clinical depression, suggest a paradigm shift from the monoamine neurotransmitters to the opioids either alone or in interaction with monoamine neurons. We have a special interest in dynorphin, the...