Synthetic studies of neoclerodane diterpenes from Salvia divinorum: exploration of the 1-position.
Bioorganic & Medicinal Chemistry Letters November 15, 2007 Kenneth G Holden, Kevin Tidgewell, Alfred Marquam et al.
Modification of the C-1 ketone of salvinorin A (2a) produces analogues with opioid antagonist properties. Of particular significance is the finding that 1-deoxo-1,10-dehydrosalvinorin A (11a) is a moderately potent antagonist at all three opioid receptor subtypes, and that herkinorin (2b), a mu agonist, is converted to a weak antagonist by removal of the C-1 ketone (3b and 11b). These...