Intranasal Ketamine Alleviates Depressive-like Behaviors in Chronic Unpredictable Mild Stress Rats in Association with Hypothalamic NADH:Ubiquinone Oxidoreductase Subunit A10.
European Journal of Pharmacology July 19, 2026 Yongning Lv, Zihe Yang, Linjie Li et al.
Intranasal ketamine represents a rapid and minimally invasive antidepressant strategy, yet the molecular mechanisms underlying its antidepressant-like effects after intranasal administration remain incompletely understood. Male Sprague-Dawley rats were subjected to a 28-day chronic unpredictable mild stress (CUMS) paradigm and then received intranasal racemic ketamine at 8.58 mg/kg twice weekly...
DOI: 10.1016/j.ejphar.2026.179153 (opens in new tab)
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Cums
Hypothalamus
Intranasal ketamine
Mitochondrial complex i
+2