Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis
Proceedings of the National Academy of Sciences December 13, 2005 Gabriella Gobbi, Francis Rodriguez Bambico, Regina A. Mangieri et al. 675 citations
Although anecdotal reports suggest that cannabis may be used to alleviate symptoms of depression, the psychotropic effects and abuse liability of this drug prevent its therapeutic application. The active constituent of cannabis, delta9-tetrahydrocannabinol, acts by binding to brain CB1 cannabinoid receptors, but an alternative approach might be to develop agents that amplify the actions of...