Intratarget Microdosing for Deep Phenotyping of Multiple Drug Effects in the Live Brain
Frontiers in Bioengineering and Biotechnology March 18, 2022 Jennifer Kim, Sebastian W. Ahn, Kyle Deans et al.
A main impediment to effective development of new therapeutics for central nervous system disorders, and for the in vivo testing of biological hypotheses in the brain, is the ability to rapidly measure the effect of novel agents and treatment combinations on the pathophysiology of native brain tissue. We have developed a miniaturized implantable microdevice (IMD) platform, optimized for direct...