Microdosing Transdermal Buprenorphine to Transition a Patient off a Higher-Dose Methadone Regimen
Hannan Moses Braun, Kristy L. Blackwood, Jeffrey P. Bratberg et al.
Abstract Background Buprenorphine is a partial µ-opioid agonist with high receptor binding affinity and long half-life—qualities that reduce overdose risk with concomitant opioid use, though may precipitate withdrawal by displacing full agonists. Traditional buprenorphine induction typically requires patients endure moderate withdrawal prior to initiation, with challenges intensifying for...