Accelerator Mass Spectrometry and Positron Emission Tomography in Human Microdosing
Pharmaceutical Sciences Encyclopedia December 16, 2011 Zhengdong Cheng
AbstractHuman microdosing study is one type of exploratory phase I investigation supported by both U.S. and European regulatory agencies. Very small subpharmacologic doses of a drug are used in humans to obtain an early assessment of pharmacokinetic properties in humans. This has the potential of reducing the number of preclinical animal studies, essential for conducting early clinical human...