PK and PK / PD Modeling of Bcl2 Inhibitor S65487 in Patients With AML and Investigation of Nonlinearity With Microdosing
CPT Pharmacometrics & Systems Pharmacology June 17, 2026 Chloé Burlot, François Riglet, Mathilde Romagnoli et al.
This work aims to assess the S65487-induced disruption of the B-cell lymphoma-2 (Bcl2)/Bcl2-like protein 11 (Bim) complex at therapeutic doses via a pharmacokinetic/pharmacodynamic model and to reconcile pharmacokinetic data from microdoses and therapeutic doses in a single population pharmacokinetic model. The first model consists of a linear 3-compartment pharmacokinetic model linked to an...