Effects of a psychedelic 5-HT2A receptor agonist on anxiety-related behavior and fear processing in mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology June 1, 2022 Błażej D. Pędzich, Sarah Rubens, Mehdi Sekssaoui et al.
Psychedelic-assisted psychotherapy gained considerable interest as a novel treatment strategy for fear-related mental disorders but the underlying mechanism remains poorly understood. The serotonin 2A (5-HT2A) receptor is a key target underlying the effects of psychedelics on emotional arousal but its role in fear processing remains controversial. Using the psychedelic 5-HT2A/5-HT2C receptor...