Background and aims. Depression is highly prevalent, and 30%–60% of patients do not respond adequately to standard therapy. Ketamine-assisted psychotherapy (KAP) is a promising approach, but psychiatric contraindications remain unstandardized. This study aimed to systematize mental health-related contraindications to ketamine-assisted therapy. Material and methods. We reviewed 74 publications,...
Relevance. Depression is one of the leading causes of disability worldwide, and a significant proportion of patients suffer from treatment-resistant forms of the disorder. An innovative approach involves the use of ketamine and esketamine, which are capable of inducing a “window of neuroplasticity” – a period of enhanced synaptogenesis and the formation of new neural connections. Theoretically,...
Background. Ketamine provides rapid but short-lived antidepressant effects for treatment-resistant depression (TRD). To prolong this response, ketamine-assisted therapy (KAT) combines the drug's pharmacological effects with psychotherapy. Aim. This study aims to analyze scientific evidence regarding the synergistic interaction between ketamine's pharmacological effects and modern...