Overlap in the neural circuitry and molecular mechanisms underlying ketamine abuse and its use as an antidepressant.
Behavioural Brain Research February 13, 2020 S. Kokane, Ross J. Armant, Carlos A. Bolaños-Guzmán et al.
Ketamine, a dissociative anesthetic and psychedelic compound, has revolutionized the field of psychopharmacology by showing robust, and rapid-acting antidepressant activity in patients suffering from major depressive disorder (MDD), suicidal tendencies, and treatment-resistant depression (TRD). Ketamine’s efficacy, however, is transient, and patients must return to the clinic for repeated...