The novel ketamine analog methoxetamine produces dissociative-like behavioral effects in rodents.
Psychopharmacology April 1, 2016 Adam L. Halberstadt, Natalia Slepak, James Hyun et al.
Methoxetamine (MXE) is a ketamine analog sold online that has been subject to widespread abuse for its dissociative and hallucinogenic effects. Previous studies have shown that MXE has high affinity for the phencyclidine (PCP) binding site located within the channel pore of the NMDA receptor (NMDAR), but little is known about its behavioral effects. Dissociative anesthetics such as ketamine and...