The role of NMDARs in the anesthetic and antidepressant effects of ketamine.
CNS Neuroscience & Therapeutics April 1, 2024 Liang Zhou, Jingjing Duan
As a phencyclidine (PCP) analog, ketamine can generate rapid-onset and substantial anesthetic effects. Contrary to traditional anesthetics, ketamine is a dissociative anesthetic and can induce loss of consciousness in patients. Recently, the subanaesthetic dose of ketamine was found to produce rapid-onset and lasting antidepressant effects. However, how different concentrations of ketamine can...