A Review of NMDA Receptors and the Phencyclidine Model of Schizophrenia
Pharmacotherapy January 2, 1996 Sheri A. Thornberg, S. R. Saklad
Current models of drug‐induced psychosis insufficiently describe the symptoms of schizophrenia. Phencyclidine‐induced psychosis is a model that more completely reflects the pathophysiology of the disease. By decreasing glutamatergic neurotransmission, phencyclidine decreases 7‐aminobutyric acid release from the nucleus accumbens, striatum, and hippocampus (manifested by MK‐801); may inhibit...