Computerized measurement of MK-801-elicited popping and hyperactivity in mice.
Clinical Neuropharmacology October 1, 1995 Richard B Rosse, John Mastropaolo, D M Sussman et al.
MK-801, a high-affinity phencyclidine (PCP) analogue, is a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) subclass of glutamate receptor that elicits hyperactivity, stereotypic behaviors, and "popping," an explosive episodic jumping behavior, in mice. The schizophreniform psychosis precipitated by PCP in humans has stimulated interest in studying MK-801-elicited mouse behaviors...