The amino acid L-lysine blocks the disruptive effect of phencyclidine on prepulse inhibition in mice.
Psychopharmacology May 1, 2007 Erik Pålsson, Kim Fejgin, Caroline Wass et al.
The cognitive and attentional deficits observed in schizophrenic patients are now considered central to the pathophysiology of the disorder. These deficits include an inability to filter sensory input as measured by, e.g., prepulse inhibition (PPI) reflex. Administration of phencyclidine (PCP), a drug that can induce a schizophrenia-like psychosis in humans, disrupts PPI in experimental...