Mouse strain differences in phencyclidine-induced behavioural changes.
The International Journal of Neuropsychopharmacology July 1, 2012 Akihiro Mouri, Takenao Koseki, Shiho Narusawa et al.
Administration of phencyclidine (PCP) is acknowledged to generate a model of psychosis in animals. With the identification of genetic susceptibility factors for schizophrenia and bipolar disorder, great efforts have been made to generate genetic animal models for major mental illnesses. As these disorders are multifactorial, comparisons among drug-induced (non-genetic) and genetic models are...