Andrea De Bartolomeis

2 papers in the library · publishing 2015

Papers

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D-aspartate dysregulation in Ddo(-/-) mice modulates phencyclidine-induced gene expression changes of postsynaptic density molecules in cortex and striatum.

Progress in Neuro-Psychopharmacology and Biological Psychiatry October 1, 2015 Andrea De Bartolomeis, Francesco Errico, Giuseppe Aceto et al.

N-methyl-D-aspartate receptor (NMDAR) hypofunction has been considered a key alteration in schizophrenia pathophysiology. Thus, several strategies aimed at enhancing glutamatergic transmission, included the introduction in therapy of D-amino acids, such as D-serine and D-cycloserine augmentation, have been proposed to counteract difficult-to-treat symptoms or treatment-resistant forms of...

DOI: 10.1016/j.pnpbp.2015.05.003 Full text Homer Nmdar Psd-95 Psychosis +1

Increased Signaling via Adenosine A1 Receptors, Sleep Deprivation, Imipramine, and Ketamine Inhibit Depressive-like Behavior via Induction of Homer1a

Neuron August 5, 2015 Tsvetan Serchov, H. Clement, M. Schwarz et al.

SUMMARY Major depressive disorder is among the most commonly diagnosed disabling mental diseases. Several non-pharmacological treatments of depression upregulate adenosine concentration and/or adenosine A1 receptors (A1R) in the brain. To test whether enhanced A1R signaling mediates antidepressant effects, we generated a transgenic mouse with enhanced doxycycline-regulated A1R expression,...

DOI: 10.1016/j.neuron.2015.07.010 Full text