Anne S Vogel

Role of the nitric oxide donor sodium nitroprusside in the antidepressant effect of ketamine in mice.

European Neuropsychopharmacology October 1, 2015 Miriam A Vogt, Anne S Vogel, Natascha Pfeiffer et al.

Ketamine may represent an efficient alternative antidepressant with rapid therapeutic onset; however, the clinical use of ketamine is hampered by psychosis-like side-effects. Recent studies suggest that the nitric oxide (NO) donor sodium nitroprusside (SNP) prevents psychosis-like abnormalities triggered by ketamine or another NMDA receptor (NMDAR) antagonist, phencyclidine (PCP) in rats. SNP...