Pharmacokinetics and pharmacodynamics of dextromethorphan: clinical and forensic aspects
Drug metabolism reviews (Softcover ed.) April 2, 2020 Ana Rita Almeida Calixto Silva, R. Dinis-Oliveira
Abstract Dextromethorphan (DXM) is a safe and effective antitussive agent present in several over the counter cough and cold medications. At higher doses, it causes psychoactive effects, making it appealing for abuse. In this work, the pharmacokinetics and pharmacodynamics of DXM with clinical and forensic relevance were extensively reviewed. DXM and related known metabolizing enzymes and...