Role of the NMDA receptor subunit in the expression of the discriminative stimulus effect induced by ketamine.
European Journal of Pharmacology June 29, 2001 M Narita, K Yoshizawa, M Nomura et al.
Ketamine, which is a non-competitive NMDA receptor antagonist, has been used as a dissociative anesthetic agent. However, chronic use of ketamine produces psychotomimetic effects, such as nightmares, hallucination and delusion. Therefore, the present study was designed to ascertain the role of the NMDA receptor and sigma receptor in the discriminative stimulus effect induced by ketamine....