Elliot W McClure

Classics in Chemical Neuroscience: Dextromethorphan (DXM).

ACS Chemical Neuroscience June 21, 2023 Elliot W McClure, R Nathan Daniels

Dextromethorphan (DXM) was introduced in 1958 as the first non-opioid cough suppressant and is indicated for multiple psychiatric disorders. It has been the most used over-the-counter cough suppressant since its emergence. However, individuals quickly noticed an intoxicating and psychedelic effect if they ingested large doses. DXM's antagonism at N-methyl-d-aspartate receptors (NMDAr) is...