Prolonged Remission of Major Depressive Disorder After Single Nitrous Oxide Inhalation Treatment
Frontiers in Psychiatry July 17, 2020 Peter Nagele, Frank Brown, Victoria Bass et al.
Nitrous oxide (N2O, laughing gas) has shown early promise as a rapidly acting treatment for treatmentresistant major depression (1–3). Antidepressant effects of nitrous oxide in these studies started within 2 h and lasted up to 1 week. Due to the study design, however, it was impossible to determine whether antidepressant efficacy lasted beyond 1 week after nitrous oxide administration. There...