Sex-specific electrophysiological and behavioral responses to nitrous oxide in a murine model of neuropathic pain.
Biology of Sex Differences July 7, 2026 Gemma González-Hernández, S. Torres-Sánchez, D. Sanchez-Morillo et al.
Chronic pain-depression comorbidity is characterized by sensory hypersensitivity and emotional dysregulation, and has been linked to alterations in prefrontal network connectivity. It represents a major therapeutic challenge due to its pronounced sex differences in symptom manifestation and increased treatment resistance. Nitrous oxide (N₂O), an inhalational anesthetic traditionally used for...