Alterations in temporal-spatial brain entropy in treatment-resistant depression treated with nitrous oxide: Evidence from resting-state EEG.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology March 1, 2025 Weizhuang Kong, Zhe Sun, Jing Zhu et al.
Entropy analysis can quantify the dynamic states of the brain and reflect its information processing capacity. Nitrous oxide has shown rapid antidepressant effects in treatment-resistant depression (TRD) patients, but its biomarkers are not yet established. We recruited 44 TRD patients and randomly assigned them to two groups: one received a 1-hour nitrous oxide inhalation treatment, while the...