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Simon L Hill

2 papers in the library · publishing 2014-2016

Papers

Clinical toxicity following analytically confirmed use of the synthetic cannabinoid receptor agonist MDMB-CHMICA. A report from the Identification Of Novel psychoActive substances (IONA) study.

Clinical toxicology (Philadelphia, Pa.) September 1, 2016 Simon L Hill, Javad Najafi, Michael Dunn et al.

In seven men who presented to hospitals in England between July and October 2015 after smoking 'legal high' products, analytically confirmed exposure to the synthetic cannabinoid receptor agonist MDMB-CHMICA was associated with acidosis (respiratory in three, metabolic in three, mixed in one), reduced level of consciousness (six of seven), dilated pupils (five of seven), fast heart rate (five of seven), slow heart rate (two of seven), convulsions (two of seven), and agitation (three of seven). Recovery occurred within 24 hours in all but one case where methiopropamine was also present.

Methoxetamine toxicity reported to the National Poisons Information Service: clinical characteristics and patterns of enquiries (including the period of the introduction of the UK's first Temporary Class Drug Order).

Emergency medicine journal : EMJ January 1, 2014 Simon L Hill, Siân C D Harbon, James M Coulson et al.

Between April 2010 and August 2012, the UK National Poisons Information Service received 47 telephone enquiries and 298 online database sessions about methoxetamine, a dissociative drug. After the UK placed methoxetamine under a Temporary Class Drug Order in April 2012, online sessions fell by 79% (from 151 to 32) and telephone enquiries by 80% (from 15 to 3). Clinical features reported included stimulant effects (36%), reduced consciousness (17%), dissociative effects (11%), cerebellar signs (6.4%), and acute mental health disturbances (43%). The pattern suggests reduced presentations to healthcare services, though whether the legal order caused the decline is unclear.