Luigi Ferrucci

2 papers in the library · 32 citations · publishing 2018-2022

Papers

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Comparative metabolomic analysis in plasma and cerebrospinal fluid of humans and in plasma and brain of mice following antidepressant-dose ketamine administration

Translational Psychiatry May 2, 2022 Ruin Moaddel, Panos Zanos, Cristan A Farmer et al. 32 citations

Abstract Subanesthetic-dose racemic ( R,S )-ketamine (ketamine) produces rapid, robust, and sustained antidepressant effects in major depressive disorder (MDD) and bipolar disorder (BD) and has also been shown to effectively treat neuropathic pain, complex regional pain syndrome, and post-traumatic stress disorder (PTSD). However, to date, its mechanism of action remains unclear. Preclinical...

DOI: 10.1038/s41398-022-01941-x Full text Ketamine Cerebrospinal fluid Antidepressant Pharmacology +6

Plasma metabolomic profiling of a ketamine and placebo crossover trial of major depressive disorder and healthy control subjects.

Psychopharmacology October 2018 Ruin Moaddel, Michelle Shardell, Mohammed Khadeer et al.

(R,S)-Ketamine produces rapid, robust, and sustained antidepressant effects in major depressive disorder. Specifically, its pharmacological efficacy in treatment refractory depression is considered a major breakthrough in the field. However, the mechanism of action of ketamine's rapid effect remains to be determined. In order to identify pathways that are responsible for ketamine's effect, a...

DOI: 10.1007/s00213-018-4992-7 Full text R,s-ketamine Kynurenine metabolites Metabolomics Sphingomyelins