Neural correlates of rapid antidepressant response to ketamine in bipolar disorder
Bipolar Disorders September 18, 2013 Allison C. Nugent, Nancy Diazgranados, Paul J. Carlson et al. 86 citations
OBJECTIVES: Ketamine, an N-methyl d-aspartate (NMDA) antagonist, has rapid antidepressant effects in depressed subjects with bipolar disorder (BD). Evidence supports a role for the glutamatergic system in the pathophysiology of BD. This double-blind, randomized, cross-over study sought to determine cerebral metabolic correlates of antidepressant response to ketamine. METHODS: Twenty-one...