Role of hippocampal p11 in the sustained antidepressant effect of ketamine in the chronic unpredictable mild stress model
Translational Psychiatry February 23, 2016 H-L Sun, Z-Q Zhou, G.-F. Zhang et al. 87 citations
Although ketamine shows a rapid and sustained antidepressant effect, the precise mechanisms underlying its effect are unknown. Recent studies indicate a key role of p11 (also known as S100A10) in depression-like behavior in rodents. The present study aimed to investigate the role of p11 in the antidepressant-like action of ketamine in chronic unpredictable mild stress (CUMS) rat model. The...