A moderate dose of the synthetic cannabinoid JWH-018, inhaled by 24 healthy adults with no history of mental illness, produced pronounced psychedelic and dissociative effects, including altered perception, amnesia, derealization, depersonalization, and confusion. The average dose administered was 5.52 mg. These findings indicate that synthetic cannabinoids pose a serious risk for public health by inducing psychotomimetic symptoms even in people without prior mental health issues.
5F-ADB, a synthetic cannabinoid, has been found in legal high products and biological samples, linked to serious health effects and deaths. This report describes five cases of verified 5F-ADB consumption, including three fatalities, a driving under the influence case, and a grievous bodily harm case. In four cases, 5F-ADB was detected in blood or plasma at concentrations between 0.11 and 0.57 μg/L; one case confirmed consumption via metabolite detection in postmortem fluids. Adverse effects observed include confusion (possibly psychosis), collapse, loss of consciousness, unsafe driving, and mood changes, all potentially attributable to 5F-ADB.