Abstract Our experience is pervaded with affect—positive or negative felt valence. Affect is thought to play a crucial role not just in emotions and moods, but also in perception, cognition, and decision-making. What might happen, then, if affect is disrupted? Subjects suffering from depersonalization give us an idea. There is significant evidence that depersonalization is in part an affective...
Since their introduction to mainstream culture and medicine in the middle of the 20th century, psychedelic substances have been investigated for their therapeutic potential. Research on psychedelic therapy, or the use of moderate-to-large doses of psychedelics in the context of therapy, indicates that psychedelics have great potential to treat disorders such as depression, addiction, and...