Psychedelic-inspired drug discovery using an engineered biosensor.
Cell April 28, 2021 Chunyang Dong, Calvin Ly, Lee E. Dunlap et al. 207 citations
Ligands can induce G protein-coupled receptors (GPCRs) to adopt a myriad of conformations, many of which play critical roles in determining the activation of specific signaling cascades associated with distinct functional and behavioral consequences. For example, the 5-hydroxytryptamine 2A receptor (5-HT2AR) is the target of classic hallucinogens, atypical antipsychotics, and psychoplastogens....