Pharmacological modulation of anxiety-like behavior by flumazenil, midazolam, and ketamine in rats: Evidence from aversive ultrasonic vocalizations and elevated plus maze.
Pharmacology, Biochemistry, and Behavior May 25, 2026 Marcela Unterspann, Chrysostomos Charalambous, Martin Votava et al.
Anxiety- and stress-related disorders are commonly treated using combinations of centrally acting drugs. However, the behavioral outcomes of interactions between GABAergic and glutamatergic systems remain incompletely characterized. The present study investigated the effects of flumazenil, ketamine and midazolam, and their combinations, on anxiety-like behavior in adult male rats using aversive...
DOI: 10.1016/j.pbb.2026.174216 (opens in new tab)
Ketamine
Animals
Rats, sprague-dawley
Rats, wistar
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