Complete biosynthesis of psychedelic tryptamines from three kingdoms in plants
Science Advances April 1, 2026 Paula Berman, Janka Höfer, Herschel Mehlman et al. 1 citation
-dimethyltryptamine (DMT) biosynthetic pathway in hallucinogenic plant species traditionally used in shamanic rituals for spiritual healing. Leveraging the similarities in their chemical structures, we reconstructed in one plant assay the full biosynthetic pathways of five renowned natural psychedelics; psilocin and psilocybin found in mushrooms, DMT from plants, and bufotenin and 5-methoxy-DMT...