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Comment on Esketamine 5 Years After Approval: Welcome New Data With Continuing Questions.

Am J Psychiatry September 1, 2026 DOI: 10.1176/appi.ajp.20251203 (opens in new tab)

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Characteristics	Peer reviewed
Topics	Esketamine

Abstract

Comment on Esketamine 5 Years After Approval: Welcome New Data With Continuing Questions.

Continuing Questions About Esketamine 5 Years After Approval: Response to Ahmed et al. Am J Psychiatry September 1, 2026
Post‐approval analysis finds favorable safety for esketamine nasal spray The Brown University Psychopharmacology Update November 28, 2025
Response to: Commentary on "Long-term treatment with esketamine nasal spray in patients with treatment resistant depression: Results from the ESCAPE-LTE study". Eur Neuropsychopharmacol June 5, 2026
Real-World Safety of Esketamine Nasal Spray: A Comprehensive Analysis Almost 5 Years After First Approval. American Journal of Psychiatry September 10, 2025 24 citations
Commentary on "Long-term treatment with esketamine nasal spray in patients with treatment resistant depression: Results from the ESCAPE-LTE study". Eur Neuropsychopharmacol March 16, 2026