A Minimal Computational Model of Microtubule Coupling: Exploring the Plausibility of Synaptogenesis as a Modulator of Collective Decoherence in Relation to the Cheung Glutamatergic Regimen

A computational toy model suggests that increasing the coupling strength between microtubule components, used as a proxy for synaptic and gap-junction density, can support stronger entangled states even under brain-like noise conditions. When coupling strength was increased from 0.5 to 4.0 in a simulated chain of tubulin dimers, nearest-neighbor entanglement (concurrence) rose from 0.2110 to 0.4618, while overall system purity remained stable at about 0.3918. The model tested the idea that a proposed oral combination of dextromethorphan, a CYP2D6 inhibitor, piracetam, and L-glutamine might promote synaptogenesis and electrical coupling, potentially altering collective quantum behavior. Whether this bears on biological coherence or consciousness remains highly speculative, and any links would require independent empirical study.

Study at a glance

Abstract

How subjective experience arises from brain activity remains one of the central unsolved problems in neuroscience. Orchestrated objective reduction, or Orch-OR, proposes that consciousness may depend in part on quantum computation within neuronal microtubules, but this proposal has long been criticized on the grounds that the brain’s warm, wet environment should destroy such states almost instantly. The present paper asks whether increased synaptic density and gap-junction coupling, potentially produced by a practical pharmacological intervention, could alter collective quantum behavior in a minimal computational model.The intervention considered here is the Cheung Glutamatergic Regimen, or CGR, a low-cost oral combination of dextromethorphan, a CYP2D6 inhibitor, piracetam, and L-glutamine. Early reports have hypothesized that CGR may promote synaptogenesis and strengthen electrical coupling between neurons. To test whether that idea is even quantitatively plausible in a stripped-down setting, an open quantum systems pipeline was built in QuTiP. The model simulated nearest-neighbor XY chains of tubulin dimers under brain-like noise conditions. When coupling strength J, used here only as a symbolic proxy for synaptic and gap-junction density, was increased from 0.5 to 4.0, nearest-neighbor concurrence rose from 0.2110 to 0.4618, while final system purity remained stable at about 0.3918. Additional runs with longer chains and stronger dephasing suggested that stronger coupling can partially counter thermal noise.These findings show, within a toy model, that denser coupling can support stronger entangled states even when global purity follows a broadly similar late-time course. Whether this bears on biological coherence or Orch-OR events remains highly speculative. Testable predictions include possible changes in gamma-band EEG power, anesthetic sensitivity, and performance on insight-based cognitive tasks among CGR users, but each of these would require independent empirical study. If any of these links are supported, the framework may offer a low-cost way to investigate possible connections between classical plasticity and collective quantum effects while staying within the clear limits of minimal modeling.