Dynamic Brain States With Cannabis Intoxication: Beyond "More Is Better" in Interpreting Brain Connectivity.
Biol Psychiatry July 1, 2026 DOI: 10.1016/j.biopsych.2026.05.005 (opens in new tab) via PubMed
Summary
AI-generated from the abstractCannabis intoxication does not simply increase or decrease brain connectivity; instead, it shifts the brain into more variable and less stable dynamic states. The findings indicate that intoxication leads to greater fluctuations in connectivity patterns over time, challenging the idea that more cannabis simply produces stronger effects. The authors suggest that the relationship between cannabis dose and brain connectivity is nonlinear, with different brain networks responding differently to intoxication.
Study at a glance
| Characteristics | Observational study Peer reviewed |
|---|---|
| Intervention | Cannabis |
| Key finding | Cannabis intoxication shifts brain connectivity into more variable and less stable dynamic states, challenging a simple dose-response relationship. |
Abstract
Dynamic Brain States With Cannabis Intoxication: Beyond "More Is Better" in Interpreting Brain Connectivity.