The PRISM Framework: Integrating Psychological, Regulatory, Behavioral, and Translational Domains in Psychedelic Clinical Trials
Open MIND 2026 DOI: 10.17605/osf.io/vd463 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Keywords | Clinical trial Prism Translational research Protocol science Relevance law Field mathematics Drug trial |
| Key points | Proposes that the PRISM framework can enhance safety, data integrity, and therapeutic relevance in psychedelic trials by integrating behavioral science, ethical protocol design, and real-world functional outcomes. |
Abstract
The psychedelic clinical research field has seen rapid growth in recent years, yet methodological frameworks remain fragmented, often focusing narrowly on pharmacology or subjectove self-report outcomes. The PRISM framework- Psychological Readiness, Regulatory & Ethical Safeguards, In-session Behavior Monitoring, Sense-making & Integration, and Meaningful Behavior Change- offers a translational approach that integrates behavioral science, ethical protocol design, and real-world functional outcomes to enhance safety, data integrity, and therapeutic relevance in psychedelic trials.