Psychedelic-Assisted Psychotherapy for TRD: An Umbrella Review [Clinical Psychology Topic 331]
Zenodo (CERN European Organization for Nuclear Research) April 4, 2026 DOI: 10.5281/zenodo.19417228 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Umbrella review Peer reviewed |
|---|---|
| Topics | Psilocybin Psychedelic-assisted therapy |
| Keywords | Medline Cognitive therapy Context archaeology Psychotherapist |
| Key findings | Psilocybin-assisted therapy shows consistent efficacy for depression and anxiety, with moderate to large effect sizes, supporting the Neural-Connectivity Re-set Model. |
Abstract
A high-rigor Umbrella Review (v7.0) on the Neural-Connectivity Re-set Model (NCRM) and psilocybin efficacy
Comparable studies
Other systematic reviews and meta-analyses on psilocybin and psychedelic-assisted therapy, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| A Meta-Analysis of Placebo-Controlled Trials of Psychedelic-Assisted Therapy | 2020 | Systematic review | |
| Psychedelic therapy for depressive symptoms: A systematic review and meta-analysis. Participants in studies of psychedelic therapy for depressive symptoms (Major... | 2023 | Systematic review with meta-analysis | n = 14 |
| Psilocybin-assisted therapy for depression: A systematic review and meta-analysis. Patients diagnosed with life-threatening illnesses or major depressive disorder | 2023 | Systematic review and meta-analysis | n = 686 |
| United States National Institutes of Health grant funding for psychedelic-assisted therapy clinical trials from 2006-2020. | 2022 | Systematic review | |
| Safety and risk assessment of psychedelic psychotherapy: A meta-analysis and systematic review. Human subjects in studies of psychedelic-assisted psychotherapy | 2024 | Systematic review and meta-analysis | n = 30 |